A CREB3-regulated ER–Golgi trafficking signature promotes metastatic progression in breast cancer
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چکیده
منابع مشابه
KAP1 promotes proliferation and metastatic progression of breast cancer cells.
KAP1 (TRIM28) is a transcriptional regulator in embryonic development that controls stem cell self-renewal, chromatin organization, and the DNA damage response, acting as an essential corepressor for KRAB family zinc finger proteins (KRAB-ZNF). To gain insight into the function of this large gene family, we developed an antibody that recognizes the conserved zinc fingers linker region (ZnFL) in...
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Purpose: In vivo studies have focused on the latter stages of the bone metastatic process(osteolysis), whereas little is known about earlier events, e.g., arrival, localization, and initialcolonization. Defining these initial steps may potentially identify the critical points susceptible totherapeutic intervention.Experimental Design: MDA-MB-435 human breast cancer cells enginee...
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PURPOSE In vivo studies have focused on the latter stages of the bone metastatic process (osteolysis), whereas little is known about earlier events, e.g., arrival, localization, and initial colonization. Defining these initial steps may potentially identify the critical points susceptible to therapeutic intervention. EXPERIMENTAL DESIGN MDA-MB-435 human breast cancer cells engineered with gre...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2017
ISSN: 0950-9232,1476-5594
DOI: 10.1038/s41388-017-0023-0